2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W014726
    DL-Phenylephrine hydrochloride 154-86-9 98%
    DL-Phenylephrine ((±)-Phenylephrine) hydrochloride is a selective agonist of the alpha1-adrenergic receptor, exhibiting potent vasoconstrictive activity.
    DL-Phenylephrine hydrochloride
  • HY-W019878
    β-Endorphin, rat 59887-17-1 98%
    β-Endorphin, rat (β-Lipotropin 61-91), a neuropeptide, is involved in cardiovascular regulation. β-Endorphin, rat induces marked, prolonged muscular rigidity and immobility similar to a catatonic state in rats.
    β-Endorphin, rat
  • HY-W040167
    VPC 23153 787582-98-3 98%
    VPC 23153 is a S1P4 receptor agonist and vasoconstrictor. VPC 23153 activates the S1P4 receptor, thereby triggering vasoconstriction. VPC 23153 induces pulmonary artery contraction. VPC 23153 can be used in studies related to pulmonary arterial hypertension.
    VPC 23153
  • HY-W040176
    N-PTyrosine PA ammonium 799268-45-4 98%
    N-PTyrosine PA (N-Palmitoyl-tyrosine phosphoric acid) ammonium is a lysophosphatidic acid (LPA) receptor modulator, which exhibits weak inhibitory activity against LPA1 and partial agonist properties towards LPA5. N-PTyrosine PA ammonium inhibits the activation of LPA receptors and downstream responses by competing with agonists for binding sites. N-PTyrosine PA ammonium can induce morphological changes and aggregation, and also inhibit LPA-induced morphological changes through receptor desensitization caused by pre-incubation. N-PTyrosine PA ammonium can be used in the research of related diseases such as atherosclerosis and acute ischemic syndromes (e.g., unstable angina, myocardial infarction, stroke).
    N-PTyrosine PA ammonium
  • HY-W047432
    5-Nitro-1H-indazole-3-carbonitrile 90348-29-1 98%
    5-Nitro-1H-indazole-3-carbonitrile (DL0805) is a Rho kinase(ROCK) inhibitor with an IC50 of 6.67 μM for ROCK-I. 5-Nitro-1H-indazole-3-carbonitrile reduces Norepinephrine (HY-13715)-induced transient contraction and inhibits contraction induced by increasing external calcium in the endothelium-denuded rings of rat models. 5-Nitro-1H-indazole-3-carbonitrile has a vasorelaxant activity but high toxicity. 5-Nitro-1H-indazole-3-carbonitrile can be used for cardiovascular diseases, especially hypertension research.
    5-Nitro-1H-indazole-3-carbonitrile
  • HY-W063263
    1-Acetylpyrrolidine 4030-18-6 99.54%
    1-Acetylpyrrolidine (N-acetylpyrrolidine) is a smoking-related metabolite. 1-Acetylpyrrolidine can induce low methylation at DNA CpG site. 1-Acetylpyrrolidine can be used for the research on the mechanisms of smoking-related diseases and the development of biomarkers.
    1-Acetylpyrrolidine
  • HY-W087947
    EDTA dihydrate tripotassium 65501-24-8
    EDTA dihydrate tripotassium (Ethylenediaminetetraacetic acid dihydrate tripotassium) is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). EDTA dihydrate tripotassium has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. EDTA dihydrate tripotassium decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. EDTA dihydrate tripotassium can alleviate the liver fibrosis. EDTA dihydrate tripotassium can be used for coronary artery disease and neural system disease research.
    EDTA dihydrate tripotassium
  • HY-W091169
    N-Methyl-2-HOBA hydrochloride 63989-87-7 99.62%
    N-Methyl-2-HOBA (2-((Methylamino)methyl)phenol) hydrochloride is a methylated form of the isoketal scavenger 2-HOBA (HY-34350). N-Methyl-2-HOBA hydrochloride can be used as a negative control for the activity of 2-HOBA in a mouse model of hypertension.
    N-Methyl-2-HOBA hydrochloride
  • HY-W092110
    Phe-Tyr 17355-18-9 98%
    Phe-Tyr is an ACE inhibitor. Phe-Tyr can be isolated from wakame. Phe-Tyr exhibits mild concentration-dependent toxicity to fibroblasts. Phe-Tyr can be used in studies related to hypertension and cardiovascular diseases.
    Phe-Tyr
  • HY-W096097
    Butofilolol 58930-32-8 98%
    Butofilolol is a potent β-blocking agent used in the research of hypertension.
    Butofilolol
  • HY-W096561
    Amiquinsin 13425-92-8
    Amiquinsin is a compound with hypotensive activity. Amiquinsin is metabolized in vivo, and the major metabolite is 4-amino-6,7-dimethoxy-3-quinolinol hydrochloride hydrate. The pharmacological and toxicological properties of amiquinsin have been widely discussed.
    Amiquinsin
  • HY-W099339
    N-Ethylnicotinamide 4314-66-3 98%
    N-Ethylnicotinamide is a compound with weak vasodilatory activity. N-Ethylnicotinamide also serves as the core scaffold of the antianginal agent Nicorandil (HY-B0341) and its derivatives.
    N-Ethylnicotinamide
  • HY-W104304
    2-(3-Trifluoromethylphenyl)glycine hydrochloride 1134915-25-5 98%
    2-(3-Trifluoromethylphenyl)glycine hydrochloride is a precursor of substituted 2-acetamido-5-aryl-l, 2,4-triazolones. Substituted 2-acetamido-5-aryl-l, 2,4-triazolones are dual V1a/V2 receptor antagonists and can be used in cardiovascular disease research.
    2-(3-Trifluoromethylphenyl)glycine hydrochloride
  • HY-W115674
    Quinidine hydrochloride 1668-99-1 98%
    Quinidine hydrochloride is an orally active antiarrhythmic agent. Quinidine hydrochloride reduces the expression level of P-gp, inhibits P-gp-mediated efflux, increases the intracellular accumulation of P-gp substrates, induces PARP cleavage and Caspase-3 activation, and elevates the proportion of Apoptotic cells at the sub-G1 phase. Quinidine hydrochloride exerts sustained block and open-channel block effects on IK(f). Quinidine hydrochloride alters the urinary metabolic ratio of Amphetamine, modulates the Pentylenetetrazol-induced seizure threshold, and regulates the anticonvulsant effect of Dextromethorphan. Quinidine hydrochloride can be used in studies related to uterine sarcoma and seizures.
    Quinidine hydrochloride
  • HY-W140249
    Angiogenin Fragment (108-123) 112173-48-5 98%
    Angiogenin Fragment (108-123) is a C-terminal segment 108-123 of Angiogenin that inhibits the enzymatic and biological activities of Angiogenin.
    Angiogenin Fragment (108-123)
  • HY-W140282
    Angiotensin II antipeptide 121379-63-3 98%
    Angiotensin II antipeptide, a peptide, is an inverse agonist of AR1 receptor. Angiotensin II antipeptide is encoded by mRNA, complementary to that encoding Angiotensin II (HY-13948) itself.
    Angiotensin II antipeptide
  • HY-W169940
    NP-184 78706-11-3 98%
    NP-184 is a novel orally active antithrombotic agent. NP-184 selectively inhibits TXA2 synthase activity with an IC50 value of 4.3 μM. NP-184 has antiplatelet and antithrombotic activities. NP-184 can be used in the research of thromboembolic diseases.
    NP-184
  • HY-W175543
    Methoxyurea 3272-27-3 98%
    Methoxyurea (Compound 3) is a potential regulator of nitric oxide (NO) donors that acts on hemoglobins such as oxy-hemoglobin (OxyHb) and met-hemoglobin (MetHb). Methoxyurea is promising for research of sickle cell disease (SCD).
    Methoxyurea
  • HY-W181626
    Tiprenolol 26481-51-6 98%
    Tiprenolol is a β-adrenoceptor blocker. Tiprenolol can abolish the ventricular arrhythmias produced by adrenaline in dogs respired with halothane.
    Tiprenolol
  • HY-W184837
    m-Nisoldipine 113578-26-0 98%
    m-Nisoldipine (KR-1008) is a dihydropyridine calcium antagonist that can significantly increase cardiac output and heart index, significantly reduce the negative inotropic effect on the myocardium, and has a relatively high selectivity for the thoracic aorta. m-Nisoldipine can be used in the research of cardiovascular diseases.
    m-Nisoldipine
Cat. No. Product Name / Synonyms Application Reactivity